# The SINTART 1 study. A phase II non-randomised controlled trial of induction chemotherapy, surgery, photon-, proton- and carbon ion-based radiotherapy integration in patients with locally advanced resectable sinonasal tumours.

**Tumor:** Cabeza y cuello
**Autores:** Resteghini C
**Revista:** Eur J Cancer (2023)
**PMID:** 37164774 | **PMCID:** —
**DOI:** [10.1016/j.ejca.2023.03.033](https://doi.org/10.1016/j.ejca.2023.03.033)
**Fuente:** PubMed (abstract only)

## Relevancia
Tumores de cabeza y cuello (escamoso oro/hipo/laringe/sinonasal) tras quimioterapia de inducción: respuesta ganglionar cervical, manejo del cuello residual y desescalamiento de la radioterapia ganglionar electiva. Paralelismo con mama: la respuesta locorregional a inducción permite estratificar tratamientos posteriores y modificar el manejo quirúrgico/RT del cuello.

## Abstract
Sinonasal tumours are rare with poor prognosis. Multimodal approach including surgery is widely used, although no standard therapy has been established. This study assessed activity and safety of multimodality treatment - induction chemotherapy, surgery and radiotherapy - modulated by histology and response to ICT. 35 patients evaluable. 14 patients (40%) treated with definitive (CT)RT and 20 (57%) underwent surgery. Five-year PFS was 38%, median PFS 26 months. 5-year OS was 46%, median OS 36 months. ORR to ICT was 54% across all histotypes and 60% in SNUC subpopulation.

## Acceso
Vía [DOI](https://doi.org/10.1016/j.ejca.2023.03.033) o suscripción institucional.

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*Datos de PubMed. Citar: doi 10.1016/j.ejca.2023.03.033*
