# Evaluating Radar Reflector Localisation in Targeted Axillary Dissection in Patients Undergoing Neoadjuvant Systemic Therapy for Node-Positive Early Breast Cancer: A Systematic Review and Pooled Analysis

**Autores:** Umar Wazir, Michael J Michell, Munaser Alamoodi, Kefah Mokbel
**Revista:** Cancers (Basel) (2024)
**PMID:** 38611023 | **PMCID:** PMC11011109
**DOI:** [10.3390/cancers16071345](https://doi.org/10.3390/cancers16071345)
**Fuente:** PubMed Central (open access full-text)

## Relevancia
Revisión sistemática de 4 estudios (252 TAD) usando reflector radar (SAVI SCOUT). Tasa de localización 99.6%, recuperación 100% y concordancia SLNB-MLNB 81%. Demuestra que omitir MLNB o SLNB infraestadificaría la axila en 9.7% y 3.4% respectivamente, justificando incluir ambos componentes.

## Abstract
SAVI SCOUT or radar reflector localisation (RRL) has proven accurate in localising non-palpable breast and axillary lesions, with minimal interference with MRI. Targeted axillary dissection (TAD), combining marked lymph node biopsy (MLNB) and sentinel lymph node biopsy (SLNB), is becoming a standard post-neoadjuvant systemic therapy (NST) for node-positive early breast cancer. Compared to SLNB alone, TAD reduces the false negative rate (FNR) to below 6%, enabling safer axillary surgery de-escalation. This systematic review evaluates RRL's performance during TAD, assessing localisation and retrieval rates, the concordance between MLNB and SLNB, and the pathological complete response (pCR) in clinically node-positive patients post-NST. Four studies (252 TAD procedures) met the inclusion criteria, with a 99.6% (95% confidence [CI]: 98.9-100) successful localisation rate, 100% retrieval rate, and 81% (95% CI: 76-86) concordance rate between SLNB and MLNB. The average duration from RRL deployment to surgery was 52 days (range:1-202). pCR was observed in 42% (95% CI: 36-48) of cases, with no significant migration or complications reported. Omitting MLNB or SLNB would have under-staged the axilla in 9.7% or 3.4% (p = 0.03) of cases, respectively, underscoring the importance of incorporating MLNB in axillary staging post-NST in initially node-positive patients in line with the updated National Comprehensive Cancer Network (NCCN) guidelines. These findings underscore the excellent efficacy of RRL in TAD for NST-treated patients with positive nodes, aiding in accurate axillary pCR identification and the safe omission of axillary dissection in strong responders.

## Acceso
Artículo disponible en [PMC11011109](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11011109/) — texto completo accesible vía PubMed Central.

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*Datos de PubMed. Citar: doi 10.3390/cancers16071345*
