# Evaluating Magnetic Seed Localization in Targeted Axillary Dissection for Node-Positive Early Breast Cancer Patients Receiving Neoadjuvant Systemic Therapy: A Comprehensive Review and Pooled Analysis

**Autores:** Munaser Alamoodi, Umar Wazir, Rita A Sakr et al.
**Revista:** J Clin Med (2024)
**PMID:** 38792449 | **PMCID:** PMC11122577
**DOI:** [10.3390/jcm13102908](https://doi.org/10.3390/jcm13102908)
**Fuente:** PubMed Central (open access full-text)

## Relevancia
Análisis combinado de 9 estudios (494 pacientes) que evalúa la semilla magnética (Magseed) en TAD. Reporta tasas de localización 94.2%, recuperación 98.8% y FNR significativamente menor para MLNB (4.2%) vs SLNB (17.6%, p=0.0013). Evidencia clave para la elección de marcador en la práctica.

## Abstract
De-escalation of axillary surgery is made possible by advancements in both neoadjuvant systemic therapy (NST) and in localisation technology for breast lesions. Magseed, developed in 2013 by Dr. Michael Douk of Cambridge, United Kingdom, is a wire-free localisation technology that facilitates the localisation and retrieval of lymph nodes for staging. Targeted axillary dissection (TAD), which entails marked lymph node biopsy (MLNB) and sentinel lymph node biopsy (SLNB), has emerged as the preferred method to assess residual disease in post-NST node-positive patients. This systematic review and pooled analysis evaluate the performance of Magseed in TAD. The search was carried out in PubMed and Google Scholar. An assessment of localisation, retrieval rates, concordance between MLNB and SLNB, and pathological complete response (pCR) in clinically node-positive patients post NST was undertaken. Nine studies spanning 494 patients and 497 procedures were identified, with a 100% successful deployment rate, a 94.2% (468/497) [95% confidence interval (CI), 93.7-94.7] localisation rate, a 98.8% (491/497) retrieval rate, and a 68.8% (247/359) [95% CI 65.6-72.0] concordance rate. pCR was observed in 47.9% (220/459) [95% CI 43.3-52.6] of cases. Subgroup analysis of studies reporting the pathological status of MLNB and SLNB separately revealed an FNR of 4.2% for MLNB and 17.6% for SLNB (p = 0.0013). Mean duration of implantation was 37 days (range: 0-188). These findings highlight magnetic seed localisation's efficacy in TAD for NST-treated node-positive patients, aiding in accurate axillary pCR identification and safe de-escalation of axillary surgery in excellent responders.

## Acceso
Artículo disponible en [PMC11122577](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11122577/) — texto completo accesible vía PubMed Central.

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*Datos de PubMed. Citar: doi 10.3390/jcm13102908*
