# The value of sentinel lymph-node biopsy in women with node-positive breast cancer at diagnosis and node-negative tumour after neoadjuvant therapy: a systematic review.

**Autores:** V&#xe1;zquez Juan C, Pi&#xf1;ero Antonio, de Castro Francisco J et al
**Revista:** Clin Transl Oncol (2022)
**PMID:** 36153763 | **PMCID:** —
**DOI:** [10.1007/s12094-022-02953-1](https://doi.org/10.1007/s12094-022-02953-1)
**Fuente:** PubMed (abstract only — full text vía DOI)

## Relevancia
Revisión sistemática del manejo axilar tras NAC. Aborda tasa de falsos negativos del SLNB tras NAC.

## Abstract
To conduct a systematic review to analyse the performance of the sentinel lymph-node biopsy (SLNB) in women with node-positive breast cancer at diagnosis and node-negative tumour after neoadjuvant therapy, compared to axillary lymph-node dissection.

The more relevant databases were searched. Main outcomes were false-negative rate (FNR), sentinel lymph-node identification rate (SLNIR), negative predictive value (NPV), and accuracy. We conducted meta-analyses when appropriate.

Twenty studies were included. The pooled FNR was 0.14 (95% CI 0.11-0.17), the pooled SLNIR was 0.89 (95% CI 0.86-0.92), NPV was 0.83 (95% CI 0.79-0.87), and summary accuracy was 0.92 (95% CI 0.90-0.94). SLNB performed better when more than one node was removed and double mapping was used.

SLNB can be performed in women with a node-negative tumour after neoadjuvant therapy. It has a better performance when used with previous marking of the affected node and with double tracer.

## Acceso
Artículo no disponible en PMC. Acceder vía [DOI](https://doi.org/10.1007/s12094-022-02953-1) o suscripción institucional.

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*Datos de PubMed. Citar: doi 10.1007/s12094-022-02953-1*
