# Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer : A systematic review.

**Autores:** Krug David, Baumann Ren&#xe9;, Budach Wilfried et al
**Revista:** Strahlenther Onkol (2018)
**PMID:** 29383405 | **PMCID:** —
**DOI:** [10.1007/s00066-018-1270-x](https://doi.org/10.1007/s00066-018-1270-x)
**Fuente:** PubMed (abstract only — full text vía DOI)

## Relevancia
Revisión sistemática del manejo axilar tras NAC. Implicaciones para radioterapia regional post-NAC según respuesta nodal.

## Abstract
To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response.

A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1 January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy.

Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports.

There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited.

## Acceso
Artículo no disponible en PMC. Acceder vía [DOI](https://doi.org/10.1007/s00066-018-1270-x) o suscripción institucional.

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*Datos de PubMed. Citar: doi 10.1007/s00066-018-1270-x*
