# Assessing the Efficacy of Radioactive Iodine Seed Localisation in Targeted Axillary Dissection for Node-Positive Early Breast Cancer Patients Undergoing Neoadjuvant Systemic Therapy: A Systematic Review and Pooled Analysis

**Autores:** Munaser Alamoodi, Umar Wazir, Janhavi Venkataraman et al.
**Revista:** Diagnostics (Basel) (2024)
**PMID:** 38893701 | **PMCID:** PMC11172271
**DOI:** [10.3390/diagnostics14111175](https://doi.org/10.3390/diagnostics14111175)
**Fuente:** PubMed Central (open access full-text)

## Relevancia
Revisión sistemática y análisis pooled de 6 estudios (574 procedimientos) sobre semillas de yodo radioactivo (¹²⁵I) en TAD. Tasa de localización 97.6%, recuperación 99.8%, y FNR de SLNB sola (18.8%) significativamente mayor que MLNB (5.3%). pCR axilar en 44%.

## Abstract
Targeted axillary dissection (TAD), employing marked lymph node biopsy (MLNB) alongside sentinel lymph node biopsy (SLNB), is increasingly recognised for its efficacy in reducing false negative rates (FNRs) in node-positive early breast cancer patients receiving neoadjuvant systemic therapy (NST). One such method, 125I radioactive seed localisation (RSL), involves implanting a seed into a biopsy-proven lymph node either pre- or post-NST. This systematic review and pooled analysis aimed to assess the performance of RSL in TAD among node-positive patients undergoing NST. Six studies, encompassing 574 TAD procedures, met the inclusion criteria. Results showed a 100% successful deployment rate, with a 97.6% successful localisation rate and a 99.8% retrieval rate. Additionally, there was a 60.0% concordance rate between SLNB and MLNB. The FNR of SLNB alone was significantly higher than it was for MLNB (18.8% versus 5.3%, respectively; p = 0.001). Pathological complete response (pCR) was observed in 44% of cases (248/564). On average, the interval from 125I seed deployment to surgery was 75.8 days (range: 0-272). These findings underscore the efficacy of RSL in TAD for node-positive patients undergoing NST, enabling precise axillary pCR identification and facilitating the safe omission of axillary lymph node dissection.

## Acceso
Artículo disponible en [PMC11172271](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172271/) — texto completo accesible vía PubMed Central.

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*Datos de PubMed. Citar: doi 10.3390/diagnostics14111175*
