# Performance of conventional MRI and endoscopy in assessing complete tumor response following immunotherapy-based neoadjuvant therapy for rectal cancer.

**Tumor:** Cáncer rectal
**Autores:** Miao G, Liu J, Tang W et al
**Revista:** Eur J Radiol (2025)
**PMID:** 40602296 | **PMCID:** —
**DOI:** [10.1016/j.ejrad.2025.112267](https://doi.org/10.1016/j.ejrad.2025.112267)
**Fuente:** PubMed (abstract only)

## Relevancia
Tumor rectal post-quimiorradioterapia neoadyuvante: aporta evidencia sobre la conversión cN+ → ypN0 en el mesorrecto, valor pronóstico de la respuesta ganglionar y selección de pacientes para watch-and-wait u organ preservation. Paralelo al carcinoma de mama: la respuesta ganglionar tras NAC es un marcador pronóstico independiente y modula la cirugía locorregional.

## Abstract
Endoscopy and MRI are essential tools for assessing treatment response in locally advanced rectal cancer (LARC). However, their accuracy in identifying pathological complete response (pCR; ie, ypT0N0) following immunotherapy-based neoadjuvant chemoradiotherapy (iNCRT) remains uncertain. This study evaluates the performance of endoscopy and MRI in reflecting ypT0 status and assesses MRI efficacy for lymph node metastasis in LARC following iNCRT.

A retrospective study was conducted on LARC patients who underwent total mesorectal excision after iNCRT between March 2022 and June 2023. A cohort of 130 NCRT-only patients was matched in a 1:2 ratio based on age, sex, and clinical stage. Restaging assessments included endoscopy, and T2-weighted/diffusion-weighted MRI (T2DWI) for primary tumors, as well as MRI for lymph node evaluation. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated, and areas under the receiver operating characteristic curves (AUCs) were determined.

Among 130 NCRT-treated patients (mean age 57.1&#xa0;years; 90 male patients), T2DWI showed comparable specificity to endoscopy (85.1&#xa0;% vs. 88.8&#xa0;%) but limited sensitivity (50&#xa0;% vs. 16.7&#xa0;%) in diagnosing ypT0. In 65 patients (mean age 56.6&#xa0;years; 45 male patients) treated with iNCRT, MRI and endoscopy showed poor performance for ypT0, with AUCs ranging from 0.54 to 0.57. A 3&#xa0;mm short-axis diameter cutoff effectively identified ypN0 status (AUC 0.76, 95&#xa0;% CI: 0.64-0.86).

Endoscopy and MRI cannot reliably identify ypT0 status, but a 3&#xa0;mm cutoff for short-axis diameter on MRI may assist in diagnosing ypN0 in LARC patients treated with iNCRT.

## Acceso
Vía [DOI](https://doi.org/10.1016/j.ejrad.2025.112267) o suscripción institucional.

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*Datos de PubMed. Citar: doi 10.1016/j.ejrad.2025.112267*
