# Data Availability Statement

**Manuscript:** Axillary management after neoadjuvant chemotherapy in node-positive breast cancer (cN+ to ypN0): an umbrella review of systematic reviews and meta-analyses (2006–2026).

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## Data and code availability

The data, code, and supporting materials underlying this umbrella review are openly available, organised as follows:

### 1. Companion open repository — primary deposit
- **URL:** https://ganglio.cicatra.com
- **Contents:**
  - 292 indexed references (catalogued in `INDICE_MAESTRO.csv`).
  - 119 retrievable open-access PDFs of the underlying articles (where copyright permits).
  - The complete corpus folder structure (`01_revisiones_metaanalisis/`, `02_ensayos_clinicos/`, `03_cancer_mama_axila/`, `04_otros_tumores/`, `05_tecnicas_quirurgicas_TAD_SLNB/`, `06_imagen_y_marcaje/`, `07_anatomia_patologica/`, `08_guias_clinicas/`, `09_radioterapia_post_NAC/`, `10_pronostico_supervivencia/`).
  - Per-reference annotation cards (clinical relevance score, key excerpts, links to full text where available).
  - Triage table (`TRIAGE_RESUMEN.md`) documenting the score-based screening process.
  - Closed-access waiting list (`pendientes_acceso_cerrado/README_PENDIENTES.md`) — none of these affect the eligible-SR set.

### 2. Extracted data and AMSTAR-2 scores
- **AMSTAR-2 scores:** `02_amstar2/amstar2_scores.csv` (machine-readable) and `02_amstar2/amstar2_detailed.md` (human-readable). Mirrored as Supplementary File **S3**.
- **Per-SR data extraction:** `03_prisma/data_extraction_filled.md` (33 SRs, one card each) and `03_prisma/sr_metadata_extracted.csv` (machine-readable). Extended with COI/GRADE/overall-confidence columns as Supplementary File **S5**.
- **PRISMA flow data:** `03_prisma/prisma_flow_data.md` (full counts and audit trail) and `03_prisma/prisma_flow.png` (PRISMA 2020 diagram).

### 3. Source code
- **AMSTAR-2 scorer:** `02_amstar2/score_amstar.py` — reproducible scoring against per-SR annotation cards.
- **SR metadata extractor:** `03_prisma/extract_sr_metadata.py` — reproducible extraction of bibliographic and methodological metadata from the corpus.
- **PRISMA flow renderer:** `03_prisma/prisma_flow.py` and `prisma_flow.dot` — Graphviz-based, reproducible diagram generation.
- **Predictor (companion clinical tool):** open-source at https://ganglio.cicatra.com — Python/JavaScript, MIT licence; integrates subtype-specific ypN0 estimates and AMSTAR-2-weighted recommendations.
- **GitHub mirror:** TBD — the full repository will be deposited at https://github.com/cicatra/predictor-ypN0 upon manuscript acceptance, with a Zenodo DOI for citation.

### 4. Search strategy and supplementary files
- **Search strategy:** `01_protocolo/search_strategy_pilot.md` — full database queries (PubMed/MEDLINE, EMBASE, CDSR, Epistemonikos), hand-search documentation, deduplication audit. Mirrored as Supplementary File **S1**.
- **PRISMA-2020 checklist:** Supplementary File **S2**.
- **Excluded studies with reasons:** Supplementary File **S4**.
- **Glossary:** Supplementary File **S6**.

### 5. Protocol and registration
- **Protocol:** `01_protocolo/PROSPERO_protocol.md` — full PROSPERO submission text (30-item structured protocol).
- **PROSPERO ID:** TBD upon registration acceptance. The registration confirmation will be appended to the published manuscript.
- **Protocol amendments:** none.

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## Licensing

| Asset class | Licence | Notes |
|---|---|---|
| Extracted data (CSV, MD, JSON) | **CC-BY 4.0** | Full reuse permitted with attribution to this publication and to https://ganglio.cicatra.com. |
| Predictor source code (front-end + back-end) | **MIT** | Free for research, education, and clinical decision support; commercial use permitted with attribution. |
| Per-SR annotation cards (text written by review team) | **CC-BY 4.0** | As above. |
| Original-publication PDFs | **Property of original publishers** | Hosted under fair-academic-use exemption only when open access; closed-access PDFs are referenced by DOI/PMID and not redistributed. |

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## No individual patient data

This work synthesises published systematic reviews and meta-analyses. No individual patient data (IPD) were obtained, and no IPD meta-analysis was performed. Ethics approval was therefore not required.

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## Persistence

- The companion repository at https://ganglio.cicatra.com is maintained by the corresponding author and is committed to ≥10-year availability.
- The GitHub mirror and Zenodo DOI (to be issued upon acceptance) provide a long-term archival copy independent of the live URL.

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*For questions about data access or for collaboration on full-text rescoring, contact the corresponding author at david@davidduque.com.*
