Umbrella Review Bundle v1.6 - 2026-05-14 (Tier 2 dual-coauthor sim)
Strict PICOS triage: 23 SRs (13 ELIGIBLE + 10 BORDERLINE) + 10 EXCLUDED
3-rater AMSTAR-2 (LLM Opus 4.7 + Sergio + David)
Tier 2 simulated coauthors: Isabel Martin-Sancho PhD (biostat) + Antonio Ramos Moreno MD (senior surgeon)
Tier 2 fixes applied: Fleiss/Gwet kappa CORRECTED to substantial (0.669/0.695); ITC reframed; NSABP B-51 qualified; PROSPERO->OSF; N narrative refined
New supplementaries: S9 methodological audit (biostat) + S10 operative-technique appendix (surgeon)
Web: https://ganglio.cicatra.com
